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Niacinamide (Vitamin B3) is indicated to reduce the appearance of skin blemishes and congestion. A high 10% concentration of this vitamin is supported in the formula by zinc salt of pyrrolidone carboxylic acid to balance visible aspects of sebum activity. Contraindications: If topical Vitamin C (L-Ascorbic Acid and/or Ethylated L-Ascorbic Acid) is used as part of skincare, it should be applied at alternate times with this formula (ideally Vitamin C in the PM and this formula in the AM). Otherwise, Niacinamide can affect integrity of the Vitamin C. Notes: While Niacinamide and Zinc PCA reduce the look of blemishes and balance visible sebum activity, neither is a treatment for acne. For persistent acne-related conditions, we recommend the use of Benzoyl Peroxide and/or Retinoic Acid. DECIEM doesn't recommend ongoing use of BHA such as Salicylic Acid for persistent blemishes. For temporary improvement in appearance of blemishes, Salicylic Acid would help. This formulation can be used alongside acne treatments if desired for added visible skin benefits. Independent studies suggest Niacinamide is also an effective ingredient for brightening skin tone. Directions: Apply to entire face morning and evening before heavier creams. If irritation occurs, cease use and consult a physician. Use only as directed on unbroken skin. Patch testing prior to use is advised.